Mutus’ lab has shown that two lysine residues, lysine 57 flanking the a domain active site, lysine 401 flanking the a’ domain active site, allow for optimal catalytic activity. Site directed mutagenesis of lysine residues 81, and 424, to glutamic acid, as well as chemical acetylation of lysine residues by treatment with acetic anhydride, will be used in order to study the effects of additional lysine residues on PDI’s activity. This research provides insight into potentially critical lysine residues which may regulate PDI’s oxioreductase activity through interactions with the CXXC motif.
I can’t wait to see what she comes up with this season. The men’s day is a favourite, particularly Topman Design and Hardy Amies, but James Long is always the highlight for me. His knitwear is outstanding and the psychedelic prints from SS11 were mind blowing, I wanted it all.
Check your utility company for green power options. Some companies will allow you to sign up for special green power programs and the CO2 savings can be huge. Plus, the more people that sign up for this option, the faster the utility companies will get the ideas that we want sustainable, responsible power options..
Over the 12 years I’ve been covering the St. Louis dining scene, I can’t remember a stronger year for new restaurants than 2017. As always with this annual guide, I seek not simply a list of 100 great restaurants but 100 great restaurants that also reflect the current character of St.
Amy, 27, isn’t a football fan (same, Amy), so when her boyfriend watches matches at the pub she stays home or does something else. She’s found her sex life taking a nosedive because her boyfriend tends to come home post game tipsy off too many beers. ‘When England won he got smashed and came home with beer down his football shirt.
We learned about flaws in the system that screens travelers.That made us wonder: What else don’t we know about Ebola?To find out, we reached out to Ebola experts to get their thoughts.Elke Muhlberger, PhD, is a microbiologist at the Boston University School of Medicine, who specializes in the study of filoviruses, the virus family to which Ebola belongs. Amesh Adalja, MD, is an infectious disease specialist at the University of Pittsburgh Medical Center. And Thomas Geisbert, PhD, is a microbiologist and immunologist who specializes in Ebola at the University of Texas Medical Branch in Galveston.Here’s their list of big questions that remain to be answered about the virus.Native Alaska Village of Point Lay Hailed for Stewardship of 35,000 WalrusesICTMN StaffWith 35,000 walruses camped out on the edge of town, the 250 population Native village of Point Lay, Alaska has been thrust onto the world stage.And, true to their custom, the residents have stepped up not to bask in their potential 15 minutes of fame, but to embrace their traditional role as environmental stewards.The walruses began arriving in mid September, as they had been for the past few years.